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Background: The transient period when the kidney donor was extracted until being anastomosed (total ischemic time) will aggravate many putative molecular ischemic-reperfusion injury mechanisms. Several studies have reported the risk of delayed graft function development, which can be reflected by creatinine serum (Cr) level and resistive index (RI) value. This study aims to determine the correlation of total ischemic time to Cr levels reduction in one-month post-transplantation and RI value.

Methods: This was a cross-sectional retrospective study involving subjects who underwent kidney transplantation in Sanglah General Hospital. In this study, the primary parameters were total ischemic time, Cr level, and RI value. The total ischemic time is calculated using a stopwatch intraoperatively. Cr level was obtained from blood examination, and RI value was obtained from the ultrasonography test. Data analysis was analyzed statistically using SPSS 24.0, and p < 0.05 was considered significant.

Results: About 17 kidney transplant subjects were included in this study. The mean total ischemic time was 105 minutes and 43 seconds. There was an insignificant negative correlation between Cr level reduction and total ischemia time (r = -0.36; p = 0.89). An analysis of the correlation of total ischemic time and RI value, there was a linear correlation, but statistically insignificant (r = 0.11; p = 0.66).

Conclusion: Total ischemic time has a negative correlation with post-transplant creatinine serum level and a positive correlation with the post-transplant resistive index value, but these results are not statistically significant.


Kidney transplantation Ischemic time Creatinine serum level Resistive index

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How to Cite
Novianti, P. A., Duarsa, G. W. K., Aditya, G. A., Oka, A. A. G., Santosa, K. B., Yudiana, I. W., Tirtayasa, P. M. W., Pramana, I. B. P., Kandarini, Y., Sudana, W., Sidartha, D., & Widiana, R. (2020). Correlation of total ischemic time to creatinine serum level and resistive index value in kidney transplant. Neurologico Spinale Medico Chirurgico, 3(2), 26-31.


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