Main Article Content
Medulloblastoma is an infratentorial primitive neuroectodermal tumor that is predominantly found in children. The incidence of medulloblastoma fluctuates between 20-35% in kids and is extraordinarily uncommon to be found in adults. A twenty-four-year-old man presented with a chief complaint of weakness of the lower extremity. Physical examination revealed myelopathy sign at the 12th thoracic level. Past medical history revealed that he had undergone total resection of a medulloblastoma of the cerebellum three years prior to the weakness. A thoracolumbar MRI with gadolinium contrast injection was performed which revealed a solid mass at thoracic vertebra 12 – lumbar 1. Four months after the total resection of the spinal mass, the patient presented again with a chief complaint of vomiting and a severe headache. A head CT scan was done followed by a head MRI with gadolinium contrast injection. A mass was found at the right temporoparietal region and craniotomy for tumor removal was immediately done to resolve the intracranial pressure problem. Pathological anatomy revealed the spinal and intracranial mass as medulloblastoma. This case report presents an adult with primary medulloblastoma of the cerebellum who presented with metastases of the spine and supratentorial regions. However, the incidence of medulloblastoma is very rare in adults and the 5-year survival rate is between 60% - 80% for all adult medulloblastoma patients. Surgeons must be careful in choosing the first management for better prognosis such as surgical management only, surgical management followed by adjuvant therapy, or just a chemotherapeutic-only approach.
This work is licensed under a Creative Commons Attribution 4.0 International License.
- Giangaspero F, Eberhart C, Haapasalo H, et al. WHO classification of tumours of the central nervous system. 4th ed. IARC; 2007:132-140.
- von Bueren AO, Friedrich C, von Hoff K, et al. Metastatic medulloblastoma in adults: Outcome of patients treated according to the HIT2000 protocol. European Journal of Cancer. 2015;51(16):2434-2443. DOI: 10.1016/j.ejca.2015.06.124
- Murase M, Saito K, Abiko T, et al. Medulloblastoma in older adults: A case report and literature review. World Neurosurgery. 2018; 117:25-31. DOI: 10.1016/j.wneu.2018.05.216
- Warren KE, Vezina G, Poussaint TY, et al. Response assessment in medulloblastoma and leptomeningeal seeding tumors: Recommendations from the response assessment in pediatric neuro-oncology committee. Neuro-Oncology. 2018;20(1):13-23. DOI: 10.1093/neuonc/nox087
- Taylor RE, Bailey CC, Robinson K, et al. Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The international society of paediatric oncology/United Kingdom children’s cancer study group pnet-3 study. JCO. 2003;21(8):1581-1591. DOI: 10.1200/JCO.2003.05.116
- Herrlinger U, Steinbrecher A, Rieger J, et al. Adult medulloblastoma: Prognostic factors and response to therapy at diagnosis and at relapse. J Neurol. 2005;252(3):291-299. DOI: 10.1007/s00415-005-0560-2
- Albright AL, Wisoff JH, Zeltzer PM, et al. Effects of medulloblastoma resections on outcome in children: A report from the children’s cancer group. Neurosurgery. 1996;38(2):265-271. DOI: 10.1097/00006123-199602000-00007
- Majd N, Penas-Prado M. Updates on management of adult medulloblastoma. Curr Treat Options in Oncol. 2019;20(8):64. DOI: 10.1007/s11864-019-0663-0
- Eibl T, Hammer A, Yakubov E, et al. Medulloblastoma in adults – reviewing the literature from a surgeon’s point of view. Aging. 2021;13(2):3146-3160. DOI: 10.18632/aging.202568